According to Ballotpedia, DePasquale earned his B.A. in political science from the College of Wooster in 1993. He went on to receive his MPA from the University of Pittsburgh in 1997.
Then, DePasquale received his J.D. from Widener University School of Law in 2002.
After earning his law degree, Depasquale began work as an attorney. He also worked for the City of York as Director of Economic Development from 2002 to 2003. Then, DePasquale worked as Deputy Secretary for the Department of Environmental Protection from 2003 to 2006.
Depasquale served as Chair of the York County Democratic Party from 1998 to 2002. He then joined the Pennsylvania House of Representatives in 2007, representing the 95th District until 2013.
On May 21, 2013, fellow Democrat Kevin Schreiber won the special election to replace DePasquale in the House.